Nerve mediated relaxation in human detrusor muscle
نویسندگان
چکیده
منابع مشابه
Pharmacological Modulation of Mucosa-Related Impairment of β-Adrenoceptor-Mediated Relaxation in Human Detrusor.
OBJECTIVES The mucosa of human detrusor strips impairs catecholamine-induced relaxation. In order to elucidate which signal transduction pathways are involved in this cross talk between the mucosa and detrusor, we have studied the effects of several pharmacological agonists and antagonists on noradrenaline-mediated relaxation in intact and mucosa-denuded detrusor strips. PATIENTS AND METHODS ...
متن کاملβ-Adrenoceptor-Mediated Relaxation of Carbachol-Pre-Contracted Mouse Detrusor.
AIMS To study the β-adrenoceptor subtypes involved in the relaxation responses to (-)-isoprenaline in carbachol-pre-contracted (CCh) mouse detrusor muscle with intact and denuded mucosa. METHODS Isolated muscle strips from the urinary bladder of male C57BL6 mice or β2-adrenoceptor knockout mice were pre-contracted with CCh, 1 µM and relaxed with increasing concentrations of the β-adrenoceptor...
متن کاملSK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions.
Animal studies suggest that the small (SK) and intermediate (IK) conductance Ca(2+)-activated K(+) channels may contribute to detrusor smooth muscle (DSM) excitability and contractility. However, the ability of SK and IK channels to control DSM spontaneous phasic and nerve-evoked contractions in human DSM remains unclear. We first investigated SK and IK channels molecular expression in native h...
متن کامل-NAD is a novel nucleotide released on stimulation of nerve terminals in human urinary bladder detrusor muscle
Breen, Leanne T., Lisa M. Smyth, Ilia A. Yamboliev, and Violeta N. Mutafova-Yambolieva. -NAD is a novel nucleotide released on stimulation of nerve terminals in human urinary bladder detrusor muscle. Am J Physiol Renal Physiol 290: F486–F495, 2006. First published September 27, 2005; doi:10.1152/ajprenal.00314.2005.—Endogenous nucleotides with extracellular functions may be involved in the comp...
متن کاملbeta-NAD is a novel nucleotide released on stimulation of nerve terminals in human urinary bladder detrusor muscle.
Endogenous nucleotides with extracellular functions may be involved in the complex neural control of human urinary bladder (HUB). Using HPLC techniques with fluorescence detection, we observed that in addition to ATP and its metabolites ADP, AMP and adenosine, electrical field stimulation (EFS; 4-16 Hz, 0.1 ms, 15 V, 60 s) of HUB detrusor smooth muscle coreleases novel nucleotide factors, which...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1993
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1993.tb00401.x